Pesquisa sobre: PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 5-PHOSPHATASES 
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Descritor Inglês:   Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases 
Descritor Espanhol:   Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatasas 
Descritor Português:   Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatases 
Sinônimos Inglês:   SHIP Phosphatases
Src Homology 2 Domain-Containing Inositol Phosphatases
Phosphatases, SHIP
Src Homology 2 Domain Containing Inositol Phosphatases  
Categoria:   D08.811.277.352.650.624.750
Definição Inglês:   Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates. 
Nota Histórica Inglês:   2017 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   56477 
Identificador Único:   D000072183 

Ocorrência na BVS:
 

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